Webp-value: 1e-2421: log p-value:-5.577e+03: FDR: NA: Information Content per bp: 1.541: Number of Target Sequences with motif: 2291.0: Percentage of Target Sequences with … WebJul 24, 2024 · GRHL2 knockdown results in CpG methylation gain and nucleosomal remodeling (reduction in permissive marks H3K4me3 and H3K27ac; elevated repressive mark H3K27me3), resembling the changes observed across progressive EMT states.
GRHL2-controlled gene expression networks in luminal …
WebApr 4, 2024 · Whole-genome sequencing identified a unique variant (c.20+544G>T) within an intronic regulatory region of GRHL2. GRHL2 gene may have a role in orbital … WebFurther analysis of the ER and H3K27Ac ChIP-seq datasets found a substantial overlap of the H3K27Ac histone modification and ER binding at the GRHL2 locus in each of the breast tumors, whereas there was no … highlight supervisor capabilities example
Genome-wide identification of binding sites of GRHL2 in luminal …
WebGRHL2 target genes are regulated by distinct ESC-specific enhancers in ESCs • GRHL2 loss results in an epithelial to mesenchymal-like transition in EpiLCs Summary The enhancer landscape of pluripotent stem cells undergoes extensive reorganization during early mammalian development. WebChIP-Seq and ChIP-qPCR demonstrated GRHL2 binding to CLDN4 and OVOL2 in both subtypes but not to other GRHL2 targets controlling cell-cell adhesion that were previously identified in other... WebMar 15, 2015 · A comparison of our GRHL2 ChIP-seq data with GRHL2 ChIP-seq data recently generated using primary human airway lung epithelial cells in culture (Gao et al., … highlight super bowl