Cisplatin resistance mechanism

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August undefined, 2024

WebSep 5, 2011 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions …

Frontiers Molecular Mechanisms of Chemotherapy …

WebAfter cisplatin enters the cells, some cisplatin molecules bind to DNA and thus activate the DNA damage-induced apoptosis cascade, 15 while others can avidly bind to cytoplasmic nucleophilic species, such as glutathione … Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need … smart home guatemala

A new mechanism of cisplatin resistance in cancer, and how to …

WebDDP has gradually become the standard chemotherapy method for chronic lung adenocarcinoma and postoperative grade II and III lung adenocarcinoma. 8 Although lung adenocarcinoma reacts well in the initial stage of standard cisplatin chemotherapy, significant DDP resistance develops before chemotherapy (primary resistance) or … WebSep 24, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms. Its most acceptable mechanism involves the formation of DNA–platinum adducts by interacting … WebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using CRISPR gene scissors, they identified the NAE1 gene as its driver. Inhibiting this resistance mediator by adding the NAE1 inhibitor MLN4924 not only restores the effect of cisplatin, … hillsborough county ticket search

Cisplatin resistance in non-small cell lung cancer cells is ... - PLOS

Effect of miR-133b on progression and cisplatin resistance of …

WebAug 24, 2024 · Components of tumor microenvironment reported to affect cisplatin resistance. These components can contribute to cisplatin resistance through decreased … WebReducing cisplatin accumulation appears to be a major mechanism of acquired resistance. In one study, variants of an ovarian carcinoma line with increasing resistance showed decreasing levels of cisplatin accumulation, which could be measured as early as 5 min following treatment. smart home hamburgWebSep 9, 2014 · Another resistance mechanism to cisplatin and oxaliplatin is increased glutathione concentration, which inactivates platinum compounds before DNA damage occurs. Metallothioneins are small cysteine-rich proteins involved in metal detoxification and may play a role as stress proteins in response to platinum complexes. 76 Once inside … hillsborough county tax assessment

"WebThe majority of cisplatin DNA lesions are repaired by the nucleotide excision repair (NER) system [ 79, 80]. One proposed mechanism for cisplatin resistance involves high expression of the high-mobility group box protein 1 (HMGB1) in TGCT cells [ 81]. " - Cisplatin resistance mechanism

Cisplatin resistance mechanism

A structure-based mechanism of cisplatin resistance mediated by …

WebApr 22, 2024 · In cisplatin-resistant cells, mitochondria are more fragmented and closer to the ER. ... BNIP3-driven mitophagy is involved in cisplatin resistance mechanism. WebOct 23, 2003 · The mechanisms responsible for cisplatin resistance are several, and contribute to the multifactorial nature of the problem. Resistance mechanisms that limit the extent of DNA damage...

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WebJun 20, 2024 · We propose here a new mechanism of cisplatin resistance mediated by glutathione transferase (GST) P1-1, as a cisplatin-binding protein. Our results show that … WebMar 20, 2024 · Cisplatin is a substrate of hOCT1 ( SLC22A1 ), hOCT2 ( SLC22A2 ), and hMATE1 ( SLC47A1 ), and oxaliplatin is a substrate of hOCT2, hOCT3 ( SLC22A3 ), …

WebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, … WebCisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA followed by activation of several signal transduction pathways …

WebNov 4, 2024 · These 13 genes identify a variety of cisplatin-resistance mechanisms including increased transport and detoxification of cisplatin, and mis-regulation of the epithelial to mesenchymal transition. Conclusions. We identified gene signatures in resistant TNBC subtypes indicative of mechanisms of cisplatin. Our results indicate … WebMar 3, 2008 · Resistance to platinum chemotherapy is multifactorial ( 2 – 6 ). There are five recognized DNA repair pathways that protect cellular DNA from injury: nucleotide excision repair, mismatch repair (MMR), double-strand break …

WebCisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes Ding-Wu Shen, Lynn M. Pouliot, Matthew D. Hall, and Michael M. Gottesman David R. Sibley, ASSOCIATE EDITOR Author informationCopyright and License informationDisclaimer

WebCisplatin DNA damage is repaired through four major mechanisms, including double-strand break repair (DSSR), mismatch repair (MMR), base excision repair (BER), and nucleotide excision repair (NER) ( Figure 2A … hillsborough county title searchWebApr 1, 2016 · Resistance to cisplatin occurs by the following molecular mechanisms: altered DNA repair, altered cellular accumulation of drug, and cytosolic inactivation of drug. The processes of resistance were studied in L1210 mouse leukemia cells and human ovarian cancer cells [7], [8], [9], [10]. smart home groupWebJan 9, 2024 · Mechanism analysis showed FAM83B interacted with APC to inhibit Wnt pathway activity, causing ovarian cancer cisplatin resistance. We also found FAM83B levels were negative with Wnt pathway ... smart home haushaltWebJul 26, 2024 · Galuzzi et al. classified the cisplatin resistance mechanisms into four categories: (i) pre-target resistance, preventing the binding of cisplatin to DNA by reduced cellular accumulation or enhanced binding to cytoplasmic components; (ii) on-target resistance, by tolerating or repairing cisplatin-DNA adducts; (iii) post-target resistance, … smart home handbuchWebCisplatin resistance. Cisplatin combination chemotherapy is the cornerstone of treatment of many cancers. Initial platinum responsiveness is high, but the majority of cancer … hillsborough county tag and titleWebFeb 25, 2024 · Autophagic flux in cisplatin-resistant ovarian cancer cells is caused by cisplatin. At present, the cytoprotective function of autophagy in cancer cells is considered a potential chemotherapy resistance mechanism. Most studies have suggested that targeting autophagy-related molecules may increase the chemosensitivity of cancer cells … smart home haierWebJul 1, 2001 · Knowledge of the mechanism of action of cisplatin has improved our understanding of resistance. Decerased intracellular concentration due to decreased … hillsborough county traffic ticket