Butein cell cycle

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August undefined, 2024

Webassays revealed butein directly interacted with Aurora B and inhibited its kinase activity. Along with the decrease of Aurora B and histone H3 phosphorylation, HCC cells were induced G2/M cell cycle arrest and subjected to cell apoptosis. Butein-mediated antitumor activities were substantially WebIn ovarian cancer, butein inhibited cell proliferation, migration, and invasion, and induced cell cycle arrest and apoptosis, and decreased the growth of ovarian cancer cells in xenograft tumor models. Butea monosperma (Fabaceae) has been used in traditional Indian medicine to treat a variety of ailments, including abdominal tumors. We aimed to …

Butein promotes ubiquitination-mediated survivin …

WebAug 27, 2014 · The flavonoid butein has been reported to show anti-inflammatory and anti-cancer effects. Following butein treatment of A549 lung cancer cells, quantitative PCR and western blot data demonstrated that COX-2 expression was suppressed at the mRNA and protein levels, respectively, and cell-cycle arrest and apoptosis were induced. WebMar 23, 2024 · Butein suppressed downstream signal transduction through higher binding affinity to IL-6. In ovarian cancer, butein inhibited cell proliferation, migration, and … stricture at the ureteropelvic junction

Butein inhibits NF-κB, AP-1 and Akt activation in adult T-cell …

WebButene, also known as butylene, is an alkene with the formula C 4 H 8.The word butene may refer to any of the individual compounds. They are colourless gases that are present in … WebIntroduction. Genomic instability, a tendency of gene alteration during the life cycle of cells, is considered to be the major driving force of tumorigenesis. 1 The genes engaged in the regulation of cell cycle arrest and DNA damage repair are considered to have an important role to maintain the stability of whole genome. 2 p53, a transcription factor which is often … WebIt was shown that butein reduced NSCLC cells proliferation and induced cell cycle arrest in G2/Mitosis phase through regulating cyclin B1, Cdc25C and Cdc2 expression levels. ... stricture at the anastomosis

Anticancer activities of cyclohexenone derivatives

Butein Inhibits Cell Proliferation and Induces Cell Cycle …

WebDownload scientific diagram Butein induced cell cycle arrest and inhibited the activation of CDK2-Cyclin E complex in RS4-11 and MOLT-4 cells. A. Cells were treated with 0, 50 or 100 μM butein ... Web4、tin.2 2) FoxO3a and its downstream molecules play a role in the synergistic effects of butein and cisplatin.23) Butein suppresses cell proliferation and enhances apoptosis in … stricture in throatWebButein had shown profound efficacy against HCC cells in vitro, and p53 was significantly stabilized and activated after butein treatment. The activation of p53 by butein was … stricture in bowel

"WebDec 1, 2024 · Butein leads to the production of ROS and induces cell cycle arrest [55], which leads to the activation of redox-signaling pathways, cell cycle arrest, cell function loss, oxidative stress, and ultimately cell death [61]. Further, the caspase-3 is activated, and the expression of Bax and Bcl-2 proteins changes which induces apoptosis [16]. " - Butein cell cycle

Butein cell cycle

Butein activates p53 in hepatocellular carcinoma cells via blocking ...

WebInt. J. Mol. Sci. 2010, 11 3 pandurata, induces apoptosis and G2/M cell cycle arrest in androgen-independent prostate cancer cells PC3 and DU145 [14]. Licochalcone A and isoliquiritigenin detected in Glycyrrhiza glabra inhibit proliferation and block cell cycle progression in the G2/M phase in PC3 and DU145 cells [15,16]. Xanthohumol identified … WebFigure 4: Butein induced cell cycle arrest and inhibited the activation of CDK2-Cyclin E complex in RS4-11 and MOLT-4 cells. A. Cells were treated with 0, 50 or 100 μM butein …

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Webof HTLV-1-infected T-cell lines. T cells cultured with butein showed obvious apoptosis morphology, and cleavage of poly(ADP-ribose) polymerase with activation of caspase-3, -8 and -9. Pretreatment of cells with caspase inhibitor partially blocked butein-induced inhibition of cell viability. Butein also resulted in cell cycle arrest at G 1 phase. WebCell Cycle Volume 11, 2012 - Issue 1. Submit an article Journal homepage. Free access. 426 Views 23 CrossRef citations to date 0. Altmetric ... Chemoresistance is a major feature of MPM. Thus, this paper explores the effect of butein (3,4,2',4'-tetrahydroxychalcone), a naturally occurring NFκB and STAT3 inhibitor, on the tumorigenic properties ...

WebNext, whether butein affected the cell cycle of CML cells was assessed, since an abnormal cell cycle is tightly associated with cell death. Butein arrested the KBM5 cells in S-phase of the cell ...

Webbutene, also called Butylene, any of four isomeric compounds belonging to the series of olefinic hydrocarbons. The chemical formula is C4H8. The isomeric forms are 1-butene, … WebSurvivin plays a crucial role in G2/M cell cycle transition and apoptosis inhibition8 ... ˜e cells were treated with Butein, and the whole-cell extract (WCE) was prepared using the commercial ...

WebIn summary, we revealed a novel mechanism by which butein induced cell cycle arrest and apoptosis in HCC cells. For the first time, Aurora B was validated to be the direct target of butein. By suppressing Aurora B, butein had substantial antitumor activities against HCC in vitro and in vivo. Supplementary Material. Supplementary figures and table.

WebMar 23, 2024 · Butein Induced Ovarian Cancer Cell Cycle Arrest and Cell Apoptosis. Cell cycle progression was monitored using flow cytometry. Exposure to butein resulted in … stricture in urethraWebNov 27, 2024 · Butein (3,4,2′,4′-tetrahydroxychalcone) inhibited inhibitor of nuclear factor kappa-B kinase subunit beta ... and 2′-hydroxy-2,4,6-trimethoxy-5′,6′-naphthochalcone induced G2/M cell cycle arrest and apoptosis . An anticancer effect was common among these chalcones. The α,β-unsaturated carbonyl group in chalcones acted as a Michael ... stricture in esophagusWeb4、tin.2 2) FoxO3a and its downstream molecules play a role in the synergistic effects of butein and cisplatin.23) Butein suppresses cell proliferation and enhances apoptosis in paclitaxel-resistant ovarian cancer cells.34) Butein activates FOXO3a/p27kip1 pathway in ALL cell lines.45) Butein inhibited . stricture bowel symptomswww.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov Lapatinib, a dual EGFR/HER2 tyrosine kinase inhibitor, has been shown to … stricture in the gastroesophageal junctionWebSep 17, 2024 · Butein treatment abrogated the radiation-induced G2/M cell cycle arrest, increased DNA damage, enhanced apoptosis, and reduced colony-forming ability of … stricture kidneyWebButein. Butein (20, 40, 3, 4-tetrahydroxychalcone), is a chalcone that has exhibited a wide range of pharmacological effects such as antiinflammatory, anticancer, antioxidant, and … stricture of bile duct icd 10WebMar 23, 2024 · In ovarian cancer, butein inhibited cell proliferation, migration, and invasion, and induced cell cycle arrest and apoptosis. In addition, it decreased the growth of ovarian cancer cells in xenograft tumor models. Butein inhibited STAT3 phosphorylation and induced FoxO3a accumulation in the nucleus by inhibiting IL-6 signaling. stricture meaning medical